To evaluate the harm associated with substances, a variety of
toxicity tests are employed. The regulations regulating the material and how it
will be utilised will determine which ones are employed. For example, toxicity testing
for a new medicine are far more extensive than those for a new cosmetic. Cell
cultures — in vitro testing – are used in several of them. By exploring the
chemical composition of a material, some of them can offer an indicator of
hazard without using cells. In other situations, computer models are employed
to determine the potential toxicity of a novel drug.
Most toxicologists
believe, however, that most of these experiments can only go so far in
predicting how a novel chemical would affect humans, and that in vivo testing
will be required at some time. There are movements across the globe – and
rightfully so – to reduce animal experimentation and, when feasible, find
alternatives. Unfortunately, when it comes to brand new materials, such as
engineered nanomaterials,
modelling and cell cultures are insufficient to anticipate how these materials
would behave in a real body.
This issue is exacerbated by the fact that several known
toxicity tests designed for chemicals
do not function well with nanomaterials. So toxicologists
are faced with a dilemma: should they depend on non-animal testing that may not
be appropriate, risking allowing dangerous items onto the market, or do they
test these things on animals to reduce the odds of anything awful happening? It's
a difficult question to answer. But, in the end, most persons involved in
ensuring that new products do not hurt people will use the most comprehensive
set of tests available to give them with the most accurate information on
product safety.
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